Tag Archives: Oncology

Where are we with Targeted Cancer Therapeutics?

In a recent project, I received a draft manuscript discussing targeted cancer therapeutics and companion diagnostics in which the writer made this statement: ”CML patients in treatment with Gleevec now have the same life expectancy as people without the disease, … Continue reading

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Gene Patents No More

As most of you know at this point, on Jun 13, 2013 the Supreme Court of the United States ruled essentially that native DNA sequences are not patentable subject matter.  The question ended up with the Supreme Court precisely because … Continue reading






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Time to Rethink Cancer Therapy?

In an earlier post, I wondered a bit about the ultimately causes of cancer.  For the last several decades cancer has been labeled as a genetic disease, an idea which we have chased with great fervor.  Yet, It feels to … Continue reading






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Lessons learned from tumor heterogeneity

My recent blog post, Tumor heterogeneity, revealed…, discussed the New England Journal of Medicine article by Gerlinger and colleagues describing the genetic heterogeneity found both within a patient’s individual tumor nodules and between spatially separate nodules.  There has been a … Continue reading






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Tumor Heterogeneity, Revealed…

A very interesting and timely article on tumor heterogeneity was published in the New England Journal of Medicine today.  Gerlinger and colleagues from the UK used next-generation sequencing to look for heterogeneity across various regions of renal tumors and metastases … Continue reading






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Failure of the Genome?

I recently read an article written by Jonathan Latham in the Guardian (UK) online with the title, “Failure of the Genome” (credit to Genome Web for pointing the post out to their readers).  Following the eye-grabbing headline, the article goes … Continue reading






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Recent Developments in DTC Genomic Testing

It’s been relatively quiet on the DTC Genomic Testing front since the turmoil over the FDA’s decision to consider regulating DTC genetic/genomic testing last summer died down.  Nevertheless, there have been a few news items that yielded glimpses of what … Continue reading






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Matching Wits with Cancer

An article and a report spurred my thinking about the complexness of the cancer cell phenotype today.  Art Levinson, the long-time CEO and now Chairman of Genentech, wrote an editorial in the 9 April 2010 issue of Science supporting changes … Continue reading






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Cancer Genes in the News Again

There seems to have been quite a bit of activity in the world of gene-based cancer diagnostics lately.  Just in the last 24 hours some of Myriad Genetics’ BRCA patents were ruled invalid in the United States (http://www.genomicslawreport.com/wp-content/uploads/2010/03/Myriad-SJ-Opinion.pdf) and a … Continue reading






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